Vitamin D and adipocytokines in GDM women and their neonates

Gestational diabetes mellitus (GDM) is associated with metabolic changes such as altered insulin secretion and insulin sensitivity.  It has also been reported that women with GDM have lower levels of Vitamin D and adipocytokine levels that is consistent with chronic inflammation.

As Vitamin D itself has anti-inflammatory properties, McManus et al. conducted a case-controlled study to evaluate Vitamin D (25(OH)D) and adipocytokine concentrations and conditions in GDM and control pregnancies. Their study shows that GDM women had lower 25(OH)D concentrations than controls, while neonatal umbilical concentrations of 25(OH)D did not differ. GDM maternal and GDM offspring had lower adiponectin, resistin and PAI-1 concentrations compared with controls. Results suggest that both GDM women and their offspring demonstrate abnormal adipocytokine patterns.

Read full article at McManus et al. (2014) Clinical Endocrinology  80 635-641; DOI: 10.1111/cen.12325