TRP63 isoforms in mammary gland and cancer

Transformation-related protein 63 (Trp63) is expressed in breast neoplasia. Specific TRP63 isoforms are linked to cell cycle arrest, apoptosis, survival, and epithelial–mesenchymal transition. Although TRP63 over-expression in cultured cells is used to elucidate functions, little is known about Trp63 regulation. Assefnia and colleagues used ChIP-seq to interrogate transcription factor binding and histone modifications of the Trp63 locus in mammary tissue. Increased expression of dominant negative isoforms was correlated with increased progesterone receptor binding to the proximal Trp63 promoter. The results contribute new information on Trp63 regulation, implicating STAT5 and defining the role of BRCA1.

Read the full article at Assefnia et al. (2014) Endocrine-Related Cancer 21 443–457. DOI:10.1530/ERC-14-0032