The ARMC5 gene shows extensive genetic variance in primary macronodular adrenocortical hyperplasia

27 Oct 2015

Correal et al. examined adrenal nodules from a patient with primary macronodular adrenocortical hyperplasia (PMAH), a rare form of Cushing’s Syndrome, for somatic variations in the ARMC5 gene. Their findings implicating ARMC5 as a tumour suppressor gene which, when silenced mediates tumourogenesis in PMAH.