T4+T3 combination therapy: is there a true effect?

02 Oct 2017


5-10% of hypothyroid patients on T4 replacement have persistent symptoms, despite normal TSH levels. T4+T3 combination therapy provided no better outcomes according to a meta-analysis of 11 randomized clinical trials comparing T4 monotherapy with T4+T3 combination therapy. A review in EJE evaluates recent developments in the field of T4+T3 therapy.

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