T1AM biodistribution in mouse

T1AM is considered to be a chemical messenger, able to interact with specific receptors and to produce functional effects. It is thought to derive from thyroid hormone through decarboxylation and deiodination, although the precise pathway and site of T1AM production remain to be established.

When assaying endogenous T1AM in rat tissues Chiellini et al. observed that T1AM concentration was higher in each tested organ (ie liver, kidney, muscle, heart, lung, and brain) than in blood. This observation suggests that some tissues may be able to accumulate T1AM. Determining whether T1AM can be specifically taken up by certain organs in vivo and comparing T1AM uptake among different organs is a crucial issue to understand the physiological role of this messenger. Therefore, in the present work, radiolabeled T1AM was injected i.v. in mice at a concentration within the physiological range, and its distribution was evaluated.

A significant increase in tissue versus blood concentration occurred in gallbladder, stomach, intestine, liver, and kidney. Tissue radioactivity decreased exponentially over time, consistent with biliary and urinary excretion, and after 24 hours, 75% of the residual radioactivity was detected in liver, muscle, and adipose tissue suggesting a systemic distribution for T1AR. Chiellini et al. (2012) Journal of Endocrinology 213 223-230.

Read the full article at DOI:10.1530/JOE-12-0055