SOCS2 regulation of local GH action

The suppressor of cytokine signalling (Socs2−/−)-knockout mouse is characterised by an overgrowth phenotype due to enhanced GH signalling. Dobie and colleagues aimed to define the Socs2−/− bone phenotype and determine whether GH promotes bone mass via IGF1-dependent mechanisms. Their findings emphasise the critical role of SOCS2 in controlling local GH anabolic bone effects, providing compelling evidence to implicate SOCS2 in the regulation of GH osteoblast signalling and ultimately bone accrual, which could be independent of IGF1 production in vivo.

Read the full article at Dobie et al. (2014) Journal of Endocrinology 223 93–106 DOI:10.1530/JOE-14-0292