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Cartilage formation in the developing vertebrate embryonic limb involves a highly coordinated and orchestrated series of events, each of which is under the specific regulation of various biological factors. Prechondrogenic condensation is the most critical process in skeletal patterning. Kwon conducted a study using the ATDC5 cell line to elucidate the molecular mechanism underlying ATP oscillations in chondrogenesis.

This study demonstrates that cAMP/PKA signalling mediates ATP oscillations in chondrogenesis. These results suggest that extracellular ATP signalling via the P2X4 receptor and cAMP/PKA signaling can play a significant role in skeletal development by mediating ATP oscillations. Therefore, this study could help provide clinical insight into treatment for diseases and disorders of skeletal systems. Kwon (2012) Journal of Endocrinology 214 337-348.

Read the full article at: DOI: 10.1530/JOE-12-0131

Signalling for ATP oscillations in chondrogenesis

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