Side population in pituitary tumours

Pituitary adenomas cause significant endocrine and mass-related morbidity. Little is known about the mechanisms that underlie pituitary tumour pathogenesis. Mertens and colleagues searched for a side population (SP) in pituitary tumours which represent cells with high efflux capacity and potentially enriched for tumour stem cells (TSCs). They detected a SP in pituitary tumours and identified TSC-associated characteristics, which adds new elements to the unravelling of pituitary tumour pathogenesis and may lead to the identification of new therapeutic targets.

Read the full article at Mertens et al. (2015) Endocrine-Related Cancer 22 481–504 DOI:10.1530/ERC-15-0546