Risk of mortality and morbidity in patients with mild primary hyperparathyroidism

The majority of patients with mild primary hyperparathyroidism (PHPT) remain untreated. Yu and colleagues examined a large subset of patients from a record linkage study in Tayside, Scotland, from 1997 to 2006. Compared to matched cohorts, the risk of all cause mortality, fatal and nonfatal cardiovascular disease was increased in patients with asymptomatic PHPT, after adjusting for confounding factors including pre-existing co-morbidities and socio-economic status. The risk of developing other co-morbidities was also increased, particularly for renal failure. Studies such as this are useful for informing the National Institute of Health guidelines on surgical referral criteria. Yu et al. (2011) Clinical Endocrinology 75 169-176.

Read the full article at: DOI: 10.1111/j.1365-2265.2010.03958.x.