Research Associate, University of Bristol

Via www.jobs.ac.uk. There is currently a vacancy for a Research Associate jointly co-supervised by the School of Clinical Sciences and the Department of Engineering Mathematics at the University of Bristol. The purpose of the work is to undertake research into mechanisms of hormone signalling action. The project is funded by the BBSRC and is led by Professor Craig A McArdle (School of Clinical Sciences) and by Dr Krasimira Tsaneva-Atanasova (Department of Engineering Mathematics). It focuses on understanding signalling of the neuropeptide gonadotrophin-releasing hormone (GnRH), in biochemical, molecular and mathematical terms.

This post will involve a number of standard molecular and cellular biological techniques (cell culture, transfection, transduction, preparation of plasmid and viral vectors, western blotting, transcriptional reporters, and fluorescence microscopy) as well as automated fluorescence microscopy. GnRH is secreted in brief pulses and its effects are dependent on pulse frequency and this project will focus on cellular frequency decoding mechanisms. The importance of the work lies in the fact that GnRHR are major therapeutic targets for treatment of infertility and hormone-dependent cancers.

For informal enquiries please contact Professor C McArdle, telephone 0117 331 3077, email [email protected] or Dr K Tsaneva-Atanasova, telephone 0117 331 5603, email [email protected]. The deadline for applications is 9.00am, 31 August 2012.

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