Research Assistant: the genetic and molecular basis of human congenital hypothyroidism, University of Cambridge, UK

Added via www.jobs.ac.uk. Applications are invited for a Research Assistant position funded by the Wellcome Trust to study the genetic and molecular basis of human congenital hypothyroidism (CH). The successful candidate will work with Dr Nadia Schoenmakers and the wider molecular endocrine research group led by Professor Krishna Chatterjee, based in the Institute of Metabolic Science Metabolic Research Laboratories on the Addenbrooke's Campus. You will join a program which aims to understand the molecular basis of human genetic thyroid disease. The research will involve the identification of risk genes for CH, by analysis and follow up of rare variants identified by whole exome sequencing, using Sanger sequencing. The RA will be responsible for the optimization of a multiplexed sequencing protocol for screening candidate genes in CH; and will be required to contribute molecular biological and cell culture studies to functionally characterise pathogenic genetic variants. Such studies may also include murine models; therefore a willingness to participate in murine phenotyping would be an advantage.

Applicants should have a BSc in Biochemistry, Genetics or a related discipline with substantial experience in gene sequencing. You will also have experience in cell culture and molecular biological techniques, as well as excellent communication skills. Prior experience of next generation sequencing techniques would be an advantage.

The deadline for applications is 4 March 2013. For more information visit the job advert below.

Job advert