Progressive decline of residual follicle pool

Primary ovarian insufficiency (POI) affects approximately 1% of women below the age of 40 years, and is associated with hypoestrogenism and infertility. In a subset of POI patients, the disease is caused an autoimmune response against the ovary. In this study, Falorni and colleagues demonstrate that most autoimmune POI patients present with a preserved pool of ovarian follicles, which is progressively lost as the disease progresses. This suggests that immunomodulatory treatment could benefit these patients. Falorni et al. (2012) Clinical Endocrinology 77 453–458.

Read the full article at: DOI: 10.1111/j.1365-2265.2012.04387.x