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Polycystic ovary syndrome (PCOS) is a heterogeneous reproductive and metabolic disorder. Owing to the heterogeneity in the clinical symptoms of PCOS, the early pathophysiological mechanisms of PCOS remain unclear. Clinical, experimental, and genetic evidence supports an interaction between genetic susceptibility and the influence of maternal environment in the pathogenesis of PCOS.

In this study, Yan et al. investigated whether prenatal androgen exposure induced PCOS-related metabolic abnormalities in peripubertal female rats. Our results demonstrated that prenatal androgen excess programmed both the metabolic and the reproductive derangements of PCOS. These findings substantiate a direct relationship of in utero androgen excess with the metabolic features of PCOS in adolescents.

Read the full article in Yan et al (2013) Endocrine Connections 217 119-129 DOI: 10.1530/JOE-12-0577

Prenatal androgen excess programs metabolic abnormalities

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