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Primary hyperparathyroidism (pHPT) represents one of the most common endocrine disorders in western populations. The genetic alterations underlying the sporadic forms of pHPT remain poorly understood. Alvelos et al. performed molecular characterisation of a series of sporadic pHPT cases. The results of their study suggest that MEN1 alterations, may represent the most prevalent genetic alteration in sporadic parathyroid tumours. Alvelos et al. (2013) European Journal of Endocrinology 168, 119-128.

Read the full article at DOI: 10.1530/EJE-12-0327.

pHPT and MEN1 alterations

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