PhD: Novel Modulation Of P53 Activity in Thyroid Cancer

Via www.jobs.ac.uk. Based in the Division of Medical Sciences at the University of Birmingham, this Medical Research Council project will provide training in a wide range of molecular and cellular biology techniques. Differentiated thyroid carcinomas are the commonest endocrine cancers and their incidence is rising. Recently, we reported over-expression of PTTG Binding Factor (PBF) in papillary and follicular thyroid tumours. The precise role of PBF in cell transformation and tumourigenesis remains unclear, however. Importantly, we have recently determined that PBF binds p53 and modulates its transactivational activity, and that PBF is upregulated in response to ionising radiation (IR). Our extensive preliminary data lead us to hypothesise that high expression of PBF in thyroid and other tumours modulates p53 function, and that DNA damage events such as ionising radiation will be more likely to elicit genetic instability in thyroid cells with high PBF expression, leading to an increased chance of tumour initiation and progression.

Candidates must have at least an upper second class honours degree in a relevant subject. Informal enquiries should be made to: Dr Chris McCabe ([email protected]) or Dr Martin Read ([email protected]). To apply, please send a full CV (including a statement of research experience and names of two referees) to Karen Carter, Division of Medical Sciences, The Medical School, University of Birmingham, Birmingham, B15 2TT or email: [email protected]. Application deadline: 30 June 2008. For more information, please click on the link below.

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