Paraneoplastic hypoglcemia induced by MSFT

Hypoglycemia is a common medical emergency and is the most frequent complication induced by anti-diabetic treatment. However, it can be observed in other conditions unrelated to diabetes such as insulinoma, autoimmune disorders, and neoplasia.

 Mohammedi et al. report the case of a rare cause of severe and recurrent hypoglycemia in a 77-year-old woman with a malignant solitary fibrous tumor (MSFT). A diagnosis of  a non-islet cell tumor-induced hypoglycemia (NICTH) was established by the presence of incompletely processed precursors of IGF2 (big IGF2) in plasma electrophoresis. Therapy with corticosteroids improved hypoglycemia and clinical symptoms. NICTH is a rare cause of hypoglycemia and the authors suggest that it should be considered in patients with mesenchymal or malignant epithelial tumors suffering from recurrent episodes of hypoglycemia.

Read full Case Report at DOI: 10.1530/EDM-14-0026