Non-classical translational regulation by a GPCR

Mechanistic details of ligand-bound G protein-coupled receptor (GPCR) translational machinery are far less explored than tyrosine kinase receptor translational mechanisms. Leόn and colleagues use the FSH receptor to demonstrate that part of the translational regulations occurs by phosphorylation of the translation pre-initiation complex scaffold protein, eukaryotic initiation factor 4G (eIF4G). They also show that FSH-induced signalling led to cap-dependent translation and internal ribosome entry site-dependent translation. These data add detailed information to the molecular basis of GPCR mRNA translation. A model of these mechanisms is proposed.

Read the full article at Leόn et al. (2014) Journal of Molecular Endocrinology 52 373–382; DOI:10.1530/JME-14-0009