MRC North West England Clinical Pharmacology PhD Fellowship Scheme 2011

Applications are being invited to commence a PhD programme in October 2011 from clinical trainees in Diabetes/Endocrinology. The programme will support full costs for a three year clinical research training fellowship leading to a PhD, incorporating valuable training in Clinical Pharmacology. Enquiries are welcome (in first instance please send a CV to [email protected] and/or [email protected]) for the following projects:

1. Modelling liver endocrine function

Professors Neil Hanley and David Ray (University of Manchester) in collaboration with Dr Chris Goldring (University of Liverpool) have a collaborative research programme exploiting a range of human hepatocyte models for better understanding of hormone and drug metabolism. Better understanding of the basic mechanisms of how metabolism occurs in different individuals is a critical missing component for developing better, safer drugs and avoiding adverse effects of drug-induced liver injury.

2. Discovering the basis of glucocorticoid sensitivity.

Professors David Ray and Neil Hanley (University of Manchester) now seek clinical research fellows to determine the basis for changes in glucocorticoid sensitivity. Although the primary clinical target for glucocorticoids is chronic inflammation the clinical response is variable, and often requires high dosages, with attendant side-effects. The project will determine how glucocorticoid action is regulated in inflammation, and identify new treatment strategies for human chronic inflammatory disease.

The deadline for applications is 23 November 2010. For more information on the individual projects please contact the study leaders as mentioned above. For more information on the fellowship scheme itself and the application process please follow the link below.

Further details