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Cancer cell metabolism is a promising target for therapy. There is increasing evidence that the antidiabetic drug metformin may have potential as an anticancer agent. This study by Klubo-Gwiezdzinska and colleagues found that metformin can inhibit the growth of medullary thyroid cancer cells through the downregulation of cyclin D1, and prevent the metastasis of medullary thyroid cancer by resensitising the cancer cells to anoikis. Klubo-Gwiezdzinska et al. (2012) Endocrine-Related Cancer 19 321-330.

Read the full article at: DOI: 10.1530/ERC-12-0046

Metformin in medullary thyroid cancer

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