LEPR maintains breast cancer

After lung cancer, breast cancer is the second most common cause of cancer mortality in women. A population of cancer cells, called cancer stem cells (CSCs) may underlie tumour recurrence and metastasis in breast cancer. Zheng and colleagues previously demonstrated that the cytokine leptin, increased in obesity, promotes the survival of CSCs. They now go on to demonstrate that the inhibition of LEPR may be a promising therapeutic approach to neutralize CSCs.

Read the full article at Zheng et al. (2013) Endocrine-Related Cancer 20; 797–808; DOI: 10.1530/ERC-13-0329