KLF5 in breast cancer

Krüppel-like factor 5 (KLF5) is a transcription factor involved in cell proliferation and differentiation. To date, KLF5 has had no clinical significance in breast cancer. In this study by Takagi and colleagues, they immunolocalized KLF5 to the nucleus of breast carcinoma cells, and demonstrated an association between KLF5 and the status of the androgen receptor. KLF5 was also associated with an increased risk of recurrence and a poor clinical outcome. This work suggests that KLF5 is an androgen-responsive gene in human breast cancer, plays an important role in progression, and may be of prognostic use. Takagi et al. (2012) Endocrine-Related Cancer 19, 741-750.

Read the full article at DOI: 10.1530/ERC-12-0017