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Daka et al. found a significant inverse association between levels of sex hormone binding globulin (SHBG) and fasting serum insulin in both genders, independent of age and BMI. The associations remained when differences in fasting plasma glucose were taken into account. Subjects with type 1 diabetes exhibited higher levels of SHBG than those with type 2 diabetes and non-diabetic subjects. This suggests an inhibitory effect of insulin on liver SHBG production. Daka et al. (2013) Endocrine Connections 1, 129–133.

Read the full article at DOI: 10.1530/EC-12-0057.

Inverse association between serum insulin and SHBG

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