Increasing effectiveness of androgen deprivation

Mooso et al. showed that Filamin A (FlnA) nuclear localisation induced apoptosis in castration-resistant prostate cancer (CRPC) cells during androgen deprivation therapy (ADT). The natural product genistein-combined polysaccharide (GCP) had a similar effect, by inducing FlnA cleavage and nuclear localisation. In a mouse model of prostate cancer recurrence, GCP, but not vehicle, impeded relapse following castration. These results demonstrate the efficacy of GCP in promoting FlnA nuclear localisation in prostate cancer. Mooso et al. (2013) Endocrine-Related Cancer 19, 759–777.

Read the full article at DOI: 10.1530/ERC-12-0171.