05 Sept 2012
While IL6 can promote insulin secretion via GLP1 release and subsequent β-cell action, da Silva Krause et al. investigated the possibility that this cytokine may directly regulate pancreatic β-cell/islet metabolism and insulin secretion at physiological concentrations. They hypothesised that pancreatic β-cell exposure to various physiological concentrations of IL6 (0–100 pg/ml) and one pathological concentration (1000 pg/ml) would provoke changes in metabolism that would favour both cell defence and insulin secretion. They conducted this study on a rat clonal β-cell line and mouse islets.
Their data demonstrate that IL6 can stimulate β-cell-dependent insulin secretion via direct cell-based mechanisms. AMPK, CaMKK (an upstream kinase activator of AMPK), and the synthesis of nitric oxide appear to alter cell metabolism to benefit insulin secretion. In summary, IL6 exerts positive effects on β-cell signalling, metabolism, antioxidant status, and insulin secretion. da Silva Krause et al. (2012) Journal of Endocrinology 214 301-311.
Read the full article at: DOI: 10.1530/JOE-12-0223
Call for nominations for Awards Committee Chair
30 Oct 2024
James M Tanner Award - 2025 nominations open
30 Oct 2024
Would you like to host the BSPED annual meeting?
21 Oct 2024