IGFBP2 predicts renal function in diabetes

This study by Narayanan and colleagues points towards a potential new clinical biomarker for the long-term outcome of diabetic kidney disease. The IGF family of proteins has been repeatedly implicated in the development of diabetic nephropathy, a major complication of diabetes and the most common end-stage renal disease. In a cohort of 436 type 2 diabetics, Narayanan and colleagues found that a high IGFBP2 concentration at baseline was associated with a decreased glomerular filtration rate over an 8-year period and an increase in proteinuria, indicative of longitudinal deterioration in renal function. Narayanan et al. (2013) Endocrine Connections 1, 95–102.

Read the full article at DOI: 10.1530/EC-12-0053.