Hyperinsulinaemia promotes Her2 breast cancer metastasis

12 Jun 2013


Epidemiological studies have associated both type 2 diabetes and hyperinsulinaemia with breast cancer in women. The Her2 oncogene is associated with metastasis and poor outcome. Ferguson and colleagues used a mouse model of Her2-mediated breast cancer to demonstrate that hyperinsulinaemia results in larger, more aggressive primary tumours, with more numerous lung metastases.

Read the full article in Ferguson et al (2013) Endocrine-Related Cancer 20 391—401, DOI: 10.1530/ERC-12-0333.


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