Gpr1 loss exacerbates glucose intolerance

Chemerin regulates adipocyte differentiation and function, metabolism, and glucose homeostasis through activation of chemokine-like receptor 1 (CMKLR1). In mammals, chemerin binds to another receptor, G protein-coupled receptor 1 (GPR1); however, the function is essentially unknown. Rourke and colleagues demonstrate the effects of GPR1 deficiency on glucose homeostasis in Gpr1-knockout mice. They found that GPR1 is an active chemerin receptor, contributing to the regulation of glucose homeostasis during obesity. As mouse and human GPR1 share 47% amino acid identity, consideration of GPR1 as a functional chemerin receptor could help clarify the complex role chemerin plays in metabolic function.

Read the full article at Rourke et al. (2014) Journal of Endocrinology 222 201–215. DOI:10.1530/JOE-14-0069