GH and adipogenesis of mouse AT-MSCs

GH influences adipocyte differentiation, but both stimulatory and inhibitory effects have been described. Adipose tissue-derived mesenchymal stem cells (AT-MSCs) are multipotent and are able to differentiate into adipocytes, among other cells. Canonical Wnt/β-catenin signaling activation impairs adipogenesis. Olarescu and colleagues aimed to elucidate the role of GH on AT-MSC adipogenesis using cells isolated from male GH receptor knockout and bovine GH transgenic mice. Their results demonstrate that GH diminishes fat mass by, in part, altering the adipogenesis of MSCs.

Read the full article at Olarescu et al. (2015) Journal of Endocrinology 226 13–23. DOI:10.1530/JOE-15-0012