GEMIN4 as an MR coregulator

Pathological activation of the mineralocorticoid receptor (MR) causes cardiac fibrosis and heart failure, but clinical MR antagonist use is limited by renal hyperkalemia. Identification of coregulator proteins, may allow the development of novel tissue-selective MR modulators that confer cardiac protection without adverse renal effects. Earlier studies from this group identified a consensus motif among MR-interacting peptides. In this study, Yang and colleagues conduct transient transfection experiments which demonstrate that GEMIN4 represses agonist-induced MR transactivation in a cell-specific manner.

Read the full article at Yang et al. (2015) Journal of Molecular Endocrinology 54 149–160. DOI: 10.1530/JME-14-0078