Exercise induces adipose PLIN3 expression in women with PCOS

Polycystic ovary syndrome (PCOS) is associated with reduced adipose tissue lipolysis and impaired glucose intolerance and affects 4 – 7% of women of reproductive age. Covington et al. conducted a cross-sectional study in eight women with PCOS and eight women matched for BMI and age with normal cycles to identify differences in the gene expression of perilipins and associated targets in adipose tissue in women with PCOS before and after aerobic exercise.

Their  data highlight a previously unrecognized, potential role of PLIN3 in adipose tissue lipolysis in women with PCOS. They  show for the first time that the expression of PLIN3, along with PLIN1 and PLIN5, is greatly reduced in the adipose tissue of women with PCOS when compared with females matched for age, body composition, and metabolic phenotype. 

Read full study by Covington et al. (2015) titled “Potential effects of aerobic exercise on the expression of perilipin 3 in the adipose tissue of women with polycystic ovary syndrome: a pilot study” vol 172 iss 1, pp 47 – 58.

DOI: 10.1530/EJE-14-0492