24 Sept 2015
Hypothalamic glucose-sensing neurons regulate the expression of the key metabolic homeostasis genes POMC, AgRP, and NPY. AMP-activated protein kinase is a possible molecular mediator, but whether other signalling mediators are involved is not clear. Zhang and colleagues investigated the role of ERK1/2; their results are indicative of a novel role of ERK1/2 in glucose-regulated POMC expression and offer new mechanistic insight into hypothalamic glucose sensing.
Read the full article titled, “ERK1/2 mediates glucose-regulated POMCgene expression in hypothalamic neurons” by Juan Zhang et al. in the Journal of Molecular Endocrinology, 54 pp 125 – 135.
DOI: 10.1530/JME-14-0330
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