ER and AR receptors in thyroid cancer

There is a great amount of in vitro data regarding the expression of estrogen receptor α (ERα) and ERβ in many cancers, including thyroid cancer. Data regarding AR involvement is less abundant. Magri and colleagues investigate whether ER and AR expression leads to a more aggressive phenotype in vivo, finding that ERα and AR expression are positively associated with an aggressive phenotype, while ERβ is negatively associated with an aggressive phenotype in vivo. This pattern of expression could be used as a tool to identify high-risk patients. Magri et al. (2012) Endocrine-Related Cancer 19 463–471.

Read the full article at: DOI: 10.1530/ERC-11-0389