Effect of preptin on insulin secretion

Preptin is a novel peptide belonging to the insulin, gastro-intestinal peptide, and endocrine peptide family. Several studies have shown that preptin can enhance insulin secretion, while infusion of isolated pancreases with preptin antibodies significantly reduces glucose-mediated insulin secretion, however the mechanisms underlying this are still no clear. Cheng et al therefore aimed to characterise the effect of preptin on insulin secretion and to investigate the potential mechanism(s) responsible for this action of preptin. Their study assessed the effect of preptin on insulin secretion and investigated the link between preptin and the phospholipase C (PLC)/protein kinase C (PKC) pathway at the cellular level.

They show that preptin promotes insulin secretion in a concentration-dependent manner. Their results provide new insight into the insulin secretion of preptin, a secreted proIGF2-derived peptide that can induce greater efficacy of signal transduction resulting from PLC and PKC activation through the IGF2R. Cheng et al. (2012) Journal of Endocrinology 215 43-49.

Read full article at DOI: 10.1530/JOE-12-0176