Effect of i.p. insulin on IGF

In type 1 diabetes mellitus (T1DM), low concentrations of IGF1 and high concentrations of IGF-binding protein 1 (IGFBP1) have been reported. It has been suggested that these abnormalities in the GH–IGF1 axis are due to low insulin concentrations in the portal vein. van Dijk and colleagues hypothesized that i.p. insulin administration increases IGF1 concentrations when compared with s.c. administration. They found that with continuous i.p. insulin infusion (CIPII) treatment, parts of the GH–IGF1 axis changed in such as way as to support this hypothesis, and that the i.p. route of insulin administration is worthy of further research.

Read the full article at van Dijk et al. (2014) Endocrine Connections 3; 17–23; DOI: 10.1530/EC-13-0089