Effect of higher CG in adipocytes

Gestational diabetes mellitus (GDM) presents with moderate inflammation, insulin resistance and impaired glucose uptake, which may result from increased maternal fat mass and increased circulation of placental hormones and adipokines. In this study, Ma and colleagues investigated whether the surge in chorionic gonadotrophin (CG) secretion is a cause of inflammation and impaired insulin sensitivity in GDM. They found that higher CG levels in pregnancy possibly played a role in GDM development partly by impairing the functions of insulin, such those involved in as glucose uptake, while promoting inflammation in adipocytes.

Read the full article at Ma et al. (2015) Journal of Molecular Endocrinology 54 161–170. 

DOI: 10.1530/JME-14-0078