CypB in PRL signalling

Evidence increasingly demonstrates of role for prolactin (PRL) in the pathogenesis of human breast cancer. Cyclophilin B (CypB) is a binding partner necessary for the transactivation of PRL-responsive genes involved in breast cancer. In this study, Fang and colleagues used siRNA to examine the effect of CyB knockdown in PRL-stimulated breast cancer cells. They conclude that the absence of CypB significantly impairs PRL-induced gene expression in breast cancer cells, resulting in reduced cell growth and migration. Fang, F et al. (2010). Journal of Molecular Endocrinology, 44, 319-329.

DOI: 10.1677/JME-09-0140