Classification of grade 3 NETS

In 2010, the World Health Organisation (WHO) updated its classification of neuroendocrine tumours (NETs) based on site of origin, grade, differentiation and clinical profile. Vélayoudom-Céphise and colleagues found that some grade 3 gastroenteropancreatic (GEP) NET cases still did not fit a profile. In their retrospective study, they argue that future classifications may consider distinguishing two subgroups of grade 3 GEPNETs according to their morphological differentiation status.

Read the full article in Vélayoudom-Céphise et al (2013) Endocrine-Related Cancer 20; 649-657; DOI: 10.1530/ERC-13-0027.