Cell cycle regulation of androgen receptor

The androgen receptor (AR) is a critical oncogene in prostate cancer (PCa) development and progression. Koryakina and colleagues demonstrate that for three AR-target genes, androgen-stimulated AR transactivation is highest during the G1 phase, decreased during S-phase, and abrogated during G2/M. A combination of imaging techniques reveals nuclear AR localization during interphase and the exclusion of the majority, but not all, AR from chromatin during mitosis. Theygo on to demonstrate that AR phosphorylation on S308 by CDK1 during mitosis regulates AR localization. These findings have important implications for understanding the function of AR as an oncogene.

Read the full article at Koryakina et al. (2015) Endocrine-Related Cancer 22 249–264 DOI:10.1530/ERC-14-0454