ACE inhibition in hypercapnia

Hypercapnia (HC) increases systemic oxygen delivery and gastric mucosal oxygenation. However, it activates the renin–angiotensin–aldosterone system (RAAS), which reduces mesenteric perfusion. Vollmer and colleagues evaluated the effect of RAAS inhibition during normocapnia and HC on oral and gastric mucosal oxygenation. They found that while RAAS inhibition reduces gastric mucosal oxygenation in healthy dogs, HC not only abolishes this effect, but also increases gastric mucosal oxygenation, systemic oxygen delivery and left ventricular contractility.

Read the full article in Journal of Endocrinology 218 245–253, DOI: 10.1530/JOE-13-1032.